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SCHEDULE 13D/A Filed 2026-06-23 Event 2026-06-23 SEC 0001104659-26-076961 →

Fairmount Funds Management LLC SPYRE THERAPEUTICS, INC. SYRE

Stake: Shares: 8,835,440 Class: Common Stock, $0.0001 par value

Item 4 — Purpose of Transaction

Not extracted from this filing — typically because it's an amendment (13D/A) and Item 4 is unchanged from the parent filing. Read the raw SEC filing →

Cross-References

Insider Activity (last 365d)
34 transactions
0 buys · 27 sales · 5 awards/exercises
Issuer Cluster
4 13D/G filings on this issuer
3 other filings besides this one
Filer Track Record
18 filings by this filer
17 other filings in the data moat
Short Interest · settle 2026-07-15
DTC 9.03
12,508,710 shares short · -8.3% vs prior

Institutional Consensus · 2025-12-31

Held by elite portfolio managers
1 holder · $21.70M
Point72 Asset Mgmt

Post-Filing Returns · since 2026-06-23 on SYRE

+1 day
0.0%
+5 days
0.0%
+30 days
+6.1%
+60 days
+90 days
+180 days

Anchor price 94.23 on closest trading day on/after 2026-06-23. Source: Yahoo Finance daily adj_close (split + dividend adjusted).

Form 4 Insider Transactions · last 365d

DateInsiderRoleTypeSharesPriceValue
2026-08-03 Burrows Scott L officer Option exercise 7,500 $14.50 $109K
2026-08-03 Burrows Scott L officer Sale 5,100 $95.21 $486K
2026-08-03 Burrows Scott L officer Sale 2,300 $96.30 $221K
2026-08-03 Burrows Scott L officer Sale 100 $97.10 $10K
2026-08-03 Turtle Cameron director, officer Sale 800 $93.97 $75K
2026-08-03 Turtle Cameron director, officer Sale 7,157 $95.10 $681K
2026-08-03 Turtle Cameron director, officer Sale 5,635 $95.93 $541K
2026-08-03 Turtle Cameron director, officer Sale 1,392 $96.82 $135K
2026-08-03 Turtle Cameron director, officer Sale 16 $97.46 $2K
2026-06-25 Burrows Scott L officer Option exercise 15,000 $14.50 $218K
2026-06-25 Burrows Scott L officer Sale 5,000 $87.12 $436K
2026-06-25 Burrows Scott L officer Sale 10,000 $87.14 $871K
2026-06-23 Fairmount Funds Management LLC director C 666,680
2026-06-23 Fairmount Funds Management LLC director Sale 4,684,781 $85.31 $399.66M
2026-06-23 Fairmount Funds Management LLC director C 16,667
2026-06-22 HENDERSON MICHAEL THOMAS director Sale 20,000 $100.00 $2.00M
2026-06-03 Sloan Sheldon officer Option exercise 8,333 $27.46 $229K
2026-06-03 Sloan Sheldon officer Sale 8,333 $75.00 $625K
2026-05-01 Burrows Scott L officer Option exercise 12,500 $14.50 $181K
2026-05-01 Sloan Sheldon officer Option exercise 78,333 $27.46 $2.15M
2026-05-01 Turtle Cameron director, officer Sale 5,300 $69.54 $369K
2026-05-01 Turtle Cameron director, officer Sale 3,600 $70.77 $255K
2026-05-01 Turtle Cameron director, officer Sale 1,000 $71.76 $72K
2026-05-01 Turtle Cameron director, officer Sale 3,100 $73.14 $227K
2026-05-01 Turtle Cameron director, officer Sale 1,700 $74.23 $126K
Showing 25 of 34

Other 13D/G Filings on SPYRE THERAPEUTICS, INC.

FiledFormFilerStakeShares
2023-12-11 SC Fairmount Funds Management LLC view →
2022-02-10 SC BAKER BROS. ADVISORS LP view →
2021-03-19 SC BAKER BROS. ADVISORS LP view →

Other Filings by Fairmount Funds Management LLC

FiledFormIssuerStakeShares
2026-07-20 SCHEDULE 13D/A Crescent Biopharma, Inc. 6,593,385 view →
2026-07-01 SCHEDULE 13D/A ORUKA THERAPEUTICS, INC. ORKA 19.50% 14,553,895 view →
2026-06-23 SCHEDULE 13D/A Apogee Therapeutics, Inc. APGE 9.99% 6,713,519 view →
2026-06-09 SCHEDULE 13D/A Jade Biosciences, Inc. JBIO 19.99% 14,069,494 view →
2026-05-13 SCHEDULE 13D/A Viridian Therapeutics, Inc.\DE VRDN 17,201,800 view →
2026-01-22 SCHEDULE Apogee Therapeutics, Inc. APGE 9.99% 6,047,027 view →
2026-01-22 SCHEDULE Cogent Biosciences, Inc. COGT 9.90% 16,261,918 view →
2025-10-14 SCHEDULE Apogee Therapeutics, Inc. APGE 9.99% 5,776,881 view →
2025-09-15 SCHEDULE Dianthus Therapeutics, Inc. /DE/ DNTH 9.90% 4,052,052 view →
2025-03-10 SCHEDULE Oruka Therapeutics, Inc. ORKA 19.99% 8,511,824 view →
2024-04-01 SC Dianthus Therapeutics, Inc. /DE/ DNTH view →
2024-04-01 SC Viridian Therapeutics, Inc.\DE VRDN view →
2024-04-01 SC Apogee Therapeutics, Inc. APGE view →
2024-04-01 SC Cogent Biosciences, Inc. COGT view →
2023-12-11 SC Spyre Therapeutics, Inc. SYRE view →
2023-06-13 SC Cogent Biosciences, Inc. COGT view →
2021-09-23 SC Viridian Therapeutics, Inc.\DE VRDN view →

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