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SCHEDULE 13D/A Filed 2026-06-23 Event 2026-06-23 SEC 0001104659-26-076961 →

Fairmount Funds Management LLC → SPYRE THERAPEUTICS, INC. SYRE

Stake: — Shares: 8,835,440 Class: Common Stock, $0.0001 par value

Item 4 — Purpose of Transaction

Not extracted from this filing — typically because it's an amendment (13D/A) and Item 4 is unchanged from the parent filing. Read the raw SEC filing →

Cross-References

Insider Activity (last 365d)
75 transactions
0 buys · 61 sales · 12 awards/exercises
Issuer Cluster
6 13D/G filings on this issuer
5 other filings besides this one
Filer Track Record
22 filings by this filer
21 other filings in the data moat
Short Interest · settle 2026-09-30
DTC 8.89
12,844,608 shares short · +5.9% vs prior

Institutional Consensus · 2025-12-31

Held by elite portfolio managers
1 holder · $21.70M
Point72 Asset Mgmt

Post-Filing Returns · since 2026-06-23 on SYRE

+1 day
0.0%
+5 days
0.0%
+30 days
+6.1%
+60 days
—
+90 days
—
+180 days
—

Anchor price 94.23 on closest trading day on/after 2026-06-23. Source: Yahoo Finance daily adj_close (split + dividend adjusted).

Form 4 Insider Transactions · last 365d

DateInsiderRoleTypeSharesPriceValue
2026-10-01 King-Jones Heidy officer Option exercise 28,933 $14.50 $420K
2026-10-01 King-Jones Heidy officer Sale 400 $89.24 $36K
2026-10-01 King-Jones Heidy officer Sale 16,605 $90.35 $1.50M
2026-10-01 King-Jones Heidy officer Sale 7,228 $91.35 $660K
2026-10-01 King-Jones Heidy officer Sale 2,100 $92.70 $195K
2026-10-01 King-Jones Heidy officer Sale 2,600 $93.46 $243K
2026-10-01 Turtle Cameron director, officer Sale 600 $89.14 $53K
2026-10-01 Turtle Cameron director, officer Sale 2,683 $90.10 $242K
2026-10-01 Turtle Cameron director, officer Sale 2,638 $91.49 $241K
2026-10-01 Turtle Cameron director, officer Sale 3,989 $92.31 $368K
2026-10-01 Turtle Cameron director, officer Sale 4,990 $93.37 $466K
2026-10-01 Turtle Cameron director, officer Sale 100 $93.91 $9K
2026-10-01 Burrows Scott L officer Option exercise 7,500 $14.50 $109K
2026-10-01 Burrows Scott L officer Sale 600 $89.07 $53K
2026-10-01 Burrows Scott L officer Sale 1,500 $90.27 $135K
2026-10-01 Burrows Scott L officer Sale 2,100 $91.92 $193K
2026-10-01 Burrows Scott L officer Sale 3,071 $92.95 $285K
2026-10-01 Burrows Scott L officer Sale 229 $93.57 $21K
2026-09-30 Burrows Scott L officer Option exercise 17,500 $14.50 $254K
2026-09-30 Burrows Scott L officer Sale 17,500 $89.89 $1.57M
2026-09-02 King-Jones Heidy officer Option exercise 400 $14.50 $6K
2026-09-02 King-Jones Heidy officer Sale 400 $90.00 $36K
2026-09-02 Burrows Scott L officer Sale 18,232 $89.35 $1.63M
2026-09-01 King-Jones Heidy officer Option exercise 27,999 $14.50 $406K
2026-09-01 King-Jones Heidy officer Sale 4,845 $86.40 $419K
Showing 25 of 75

Other 13D/G Filings on SPYRE THERAPEUTICS, INC.

FiledFormFilerStakeShares
2026-10-09 SCHEDULE 13D/A Fairmount Funds Management LLC 9.99% 9,354,200 view →
2026-10-01 SCHEDULE 13G Paradigm Biocapital Advisors LP — — view →
2023-12-11 SC Fairmount Funds Management LLC — — view →
2022-02-10 SC BAKER BROS. ADVISORS LP — — view →
2021-03-19 SC BAKER BROS. ADVISORS LP — — view →

Other Filings by Fairmount Funds Management LLC

FiledFormIssuerStakeShares
2026-10-15 SCHEDULE 13D Alaunos Therapeutics, Inc. 19.99% 858,789 view →
2026-10-09 SCHEDULE 13D/A SPYRE THERAPEUTICS, INC. 9.99% 9,354,200 view →
2026-09-11 SCHEDULE 13D Korsana Biosciences, Inc. 19.99% 9,103,729 view →
2026-09-03 SCHEDULE 13D/A Apogee Therapeutics, Inc. — 0 view →
2026-07-20 SCHEDULE 13D/A Crescent Biopharma, Inc. — 6,593,385 view →
2026-07-01 SCHEDULE 13D/A ORUKA THERAPEUTICS, INC. ORKA 19.50% 14,553,895 view →
2026-06-23 SCHEDULE 13D/A Apogee Therapeutics, Inc. APGE 9.99% 6,713,519 view →
2026-06-09 SCHEDULE 13D/A Jade Biosciences, Inc. JBIO 19.99% 14,069,494 view →
2026-05-13 SCHEDULE 13D/A Viridian Therapeutics, Inc.\DE VRDN — 17,201,800 view →
2026-01-22 SCHEDULE Cogent Biosciences, Inc. COGT 9.90% 16,261,918 view →
2026-01-22 SCHEDULE Apogee Therapeutics, Inc. APGE 9.99% 6,047,027 view →
2025-10-14 SCHEDULE Apogee Therapeutics, Inc. APGE 9.99% 5,776,881 view →
2025-09-15 SCHEDULE Dianthus Therapeutics, Inc. /DE/ DNTH 9.90% 4,052,052 view →
2025-03-10 SCHEDULE Oruka Therapeutics, Inc. ORKA 19.99% 8,511,824 view →
2024-04-01 SC Cogent Biosciences, Inc. COGT — — view →
2024-04-01 SC Dianthus Therapeutics, Inc. /DE/ DNTH — — view →
2024-04-01 SC Viridian Therapeutics, Inc.\DE VRDN — — view →
2024-04-01 SC Apogee Therapeutics, Inc. APGE — — view →
2023-12-11 SC Spyre Therapeutics, Inc. SYRE — — view →
2023-06-13 SC Cogent Biosciences, Inc. COGT — — view →
Showing 20 of 21

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