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SC Filed 2021-03-19 Event — SEC 0001104659-21-039060 →

BAKER BROS. ADVISORS LP → Aeglea BioTherapeutics, Inc. SYRE

Stake: — Shares: —
Composite Decision Signal · PASS (LOW BASE-RATE EDGE) Conviction Score: 17/100 · Filer 90d Win Rate: 0% · Hist. 90d Edge: +0.0%
  • Filer track record (4 filings): 0% 90d win rate, +0.0% 90d edge
  • Elevated short days-to-cover (7.3 DTC)

Item 4 — Purpose of Transaction

Not extracted from this filing — typically because it's an amendment (13D/A) and Item 4 is unchanged from the parent filing. Read the raw SEC filing →

Cross-References

Insider Activity (last 365d)
75 transactions
0 buys · 61 sales · 12 awards/exercises
Issuer Cluster
6 13D/G filings on this issuer
5 other filings besides this one
Filer Track Record
67 filings by this filer
66 other filings in the data moat
Short Interest · settle 2026-10-15
DTC 7.34
12,505,491 shares short · -2.6% vs prior

Form 4 Insider Transactions · last 365d

DateInsiderRoleTypeSharesPriceValue
2026-10-01 King-Jones Heidy officer Option exercise 28,933 $14.50 $420K
2026-10-01 King-Jones Heidy officer Sale 400 $89.24 $36K
2026-10-01 King-Jones Heidy officer Sale 16,605 $90.35 $1.50M
2026-10-01 King-Jones Heidy officer Sale 7,228 $91.35 $660K
2026-10-01 King-Jones Heidy officer Sale 2,100 $92.70 $195K
2026-10-01 King-Jones Heidy officer Sale 2,600 $93.46 $243K
2026-10-01 Turtle Cameron director, officer Sale 600 $89.14 $53K
2026-10-01 Turtle Cameron director, officer Sale 2,683 $90.10 $242K
2026-10-01 Turtle Cameron director, officer Sale 2,638 $91.49 $241K
2026-10-01 Turtle Cameron director, officer Sale 3,989 $92.31 $368K
2026-10-01 Turtle Cameron director, officer Sale 4,990 $93.37 $466K
2026-10-01 Turtle Cameron director, officer Sale 100 $93.91 $9K
2026-10-01 Burrows Scott L officer Option exercise 7,500 $14.50 $109K
2026-10-01 Burrows Scott L officer Sale 600 $89.07 $53K
2026-10-01 Burrows Scott L officer Sale 1,500 $90.27 $135K
2026-10-01 Burrows Scott L officer Sale 2,100 $91.92 $193K
2026-10-01 Burrows Scott L officer Sale 3,071 $92.95 $285K
2026-10-01 Burrows Scott L officer Sale 229 $93.57 $21K
2026-09-30 Burrows Scott L officer Option exercise 17,500 $14.50 $254K
2026-09-30 Burrows Scott L officer Sale 17,500 $89.89 $1.57M
2026-09-02 King-Jones Heidy officer Option exercise 400 $14.50 $6K
2026-09-02 King-Jones Heidy officer Sale 400 $90.00 $36K
2026-09-02 Burrows Scott L officer Sale 18,232 $89.35 $1.63M
2026-09-01 King-Jones Heidy officer Option exercise 27,999 $14.50 $406K
2026-09-01 King-Jones Heidy officer Sale 4,845 $86.40 $419K
Showing 25 of 75

Other 13D/G Filings on Aeglea BioTherapeutics, Inc.

FiledFormFilerStakeShares
2026-10-09 SCHEDULE 13D/A Fairmount Funds Management LLC 9.99% 9,354,200 view →
2026-10-01 SCHEDULE 13G Paradigm Biocapital Advisors LP — — view →
2026-06-23 SCHEDULE 13D/A Fairmount Funds Management LLC — 8,835,440 view →
2023-12-11 SC Fairmount Funds Management LLC — — view →
2022-02-10 SC BAKER BROS. ADVISORS LP — — view →

Other Filings by BAKER BROS. ADVISORS LP

FiledFormIssuerStakeShares
2026-09-30 SCHEDULE 13D/A Kodiak Sciences Inc. 35.00% 22,049,297 view →
2026-09-16 SCHEDULE 13D/A BeOne Medicines Ltd. — 115,457,154 view →
2026-08-11 SCHEDULE 13D/A Replimune Group, Inc. 11.80% 11,075,336 view →
2026-07-16 SCHEDULE 13D/A Celcuity Inc. 9.99% 4,877,963 view →
2026-07-16 SCHEDULE 13G Celcuity Inc. — — view →
2026-06-15 SCHEDULE 13D/A BeOne Medicines Ltd. BEIGF 8.00% 115,457,154 view →
2026-05-26 SCHEDULE 13D/A Kiniksa Pharmaceuticals International, plc KNSA 7.00% 3,231,181 view →
2026-05-11 SCHEDULE 13D/A Incyte Corp INCY — 30,865,077 view →
2025-06-30 SCHEDULE Kymera Therapeutics, Inc. KYMR 9.50% 6,666,540 view →
2024-10-08 SC Kiniksa Pharmaceuticals International, plc KNSA — — view →
2024-06-14 SC INCYTE CORP INCY — — view →
2023-12-18 SC Seagen Inc. — — view →
2023-10-10 SC Neoleukin Therapeutics, Inc. NGNE — — view →
2023-10-05 SC MADRIGAL PHARMACEUTICALS, INC. MDGL — — view →
2023-07-19 SC Neoleukin Therapeutics, Inc. NGNE — — view →
2023-05-24 SC Prelude Therapeutics Inc PRLD — — view →
2023-05-24 SC ACADIA PHARMACEUTICALS INC ACAD — — view →
2023-05-03 SC Seagen Inc. — — view →
2023-03-15 SC INCYTE CORP INCY — — view →
2023-03-13 SC Seagen Inc. — — view →
Showing 20 of 66

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