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ISSUER PROFILE · CIK 0001636282

SPYRE THERAPEUTICS, INC.SYRE

4 13D/G filings 2 distinct filers 55 insider transactions (365d)

Post-Filing Returns · across 1 activist filings on this issuer

Median 30d
+6.1%
avg +6.1%
Median 60d
avg —
Median 90d
avg —
Median 180d
avg —

Returns measured from each activist filing's date_of_event, split + dividend adjusted via Yahoo Finance.

Cross-Reference Snapshot

Activist filings
4
1 SCHEDULE 13D/A · 3 SC
Distinct filers
2
multi-activist cluster
Insiders (365d)
55
0 buys · 44 sales
Latest short DTC
9.69
as of 2026-08-31

Institutional Consensus · 2025-12-31

Held by elite portfolio managers
1 holder · $21.70M
Point72 Asset Mgmt

13D/G Filings Timeline · 4 total

FiledFormFilerStakeSharesIntent
2026-06-23 SCHEDULE 13D/A Fairmount Funds Management LLC 8,835,440 view →
2023-12-11 SC Fairmount Funds Management LLC view →
2022-02-10 SC BAKER BROS. ADVISORS LP view →
2021-03-19 SC BAKER BROS. ADVISORS LP view →

Form 4 Insider Transactions · last 365d

DateInsiderRoleTypeSharesPriceValue
2026-09-02 King-Jones Heidy officer Option exercise 400 $14.50 $6K
2026-09-02 King-Jones Heidy officer Sale 400 $90.00 $36K
2026-09-02 Burrows Scott L officer Sale 18,232 $89.35 $1.63M
2026-09-01 King-Jones Heidy officer Option exercise 27,999 $14.50 $406K
2026-09-01 King-Jones Heidy officer Sale 4,845 $86.40 $419K
2026-09-01 King-Jones Heidy officer Sale 16,548 $87.20 $1.44M
2026-09-01 King-Jones Heidy officer Sale 6,206 $88.17 $547K
2026-09-01 King-Jones Heidy officer Sale 400 $89.38 $36K
2026-09-01 Burrows Scott L officer Option exercise 7,500 $14.50 $109K
2026-09-01 Burrows Scott L officer Sale 900 $86.25 $78K
2026-09-01 Burrows Scott L officer Sale 4,384 $87.11 $382K
2026-09-01 Burrows Scott L officer Sale 2,016 $88.03 $177K
2026-09-01 Burrows Scott L officer Sale 200 $89.04 $18K
2026-09-01 Turtle Cameron director, officer Sale 2,500 $86.36 $216K
2026-09-01 Turtle Cameron director, officer Sale 8,400 $87.15 $732K
2026-09-01 Turtle Cameron director, officer Sale 3,700 $88.06 $326K
2026-09-01 Turtle Cameron director, officer Sale 400 $89.07 $36K
2026-08-07 Albers Jeffrey W. director Option exercise 5,000 $10.39 $52K
2026-08-07 Albers Jeffrey W. director Sale 5,000 $104.47 $522K
2026-08-07 Albers Jeffrey W. director Sale 8,000 $104.38 $835K
2026-08-07 Albers Jeffrey W. director Sale 10,000 $104.68 $1.05M
2026-08-03 Burrows Scott L officer Option exercise 7,500 $14.50 $109K
2026-08-03 Burrows Scott L officer Sale 5,100 $95.21 $486K
2026-08-03 Burrows Scott L officer Sale 2,300 $96.30 $221K
2026-08-03 Burrows Scott L officer Sale 100 $97.10 $10K
Showing 25 of 55

FINRA Short Interest History

SettlementShort InterestDays to Cover% Δ vs prior
2026-08-31 11,859,975 9.69 +0.9%
2026-08-14 11,755,434 15.95 -3.2%
2026-07-31 12,143,879 13.52 -2.9%
2026-07-15 12,508,710 9.03 -8.3%
2026-06-30 13,640,183 5.56 +8.1%
2026-06-15 12,616,535 10.83 -0.1%
2026-05-29 12,627,576 15.47 +1.7%
2026-05-15 12,417,051 10.44 +1.6%
2026-04-30 12,221,682 10.04 +4.7%
2026-04-15 11,672,747 7.35 +11.8%
2026-03-31 10,435,737 11.48 +4.4%
2026-03-13 9,997,086 13.99 +0.1%

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