Spyre Therapeutics, Inc.SYRE

3 13D/G filings 2 distinct filers 0 insider transactions (365d)

Cross-Reference Snapshot

Activist filings

3 SC

Distinct filers

multi-activist cluster

Insiders (365d)

0 buys · 0 sales

Latest short DTC

11.48

as of 2026-03-31

Held by elite portfolio managers

1 holder · $21.70M

Point72 Asset Mgmt

Filed	Form	Filer	Stake	Shares
2023-12-11	SC	Fairmount Funds Management LLC	—	—	view →
2022-02-10	SC	BAKER BROS. ADVISORS LP	—	—	view →
2021-03-19	SC	BAKER BROS. ADVISORS LP	—	—	view →

Settlement	Short Interest	Days to Cover	% Δ vs prior
2026-03-31	10,435,737	11.48	+4.4%
2026-03-13	9,997,086	13.99	+0.1%
2026-02-27	9,985,198	12.42	+1.2%
2026-02-13	9,862,924	14.87	-1.2%
2026-01-30	9,980,496	20.29	-0.9%
2026-01-15	10,069,741	13.89	-13.5%
2025-12-31	11,636,998	14.06	-1.5%
2025-12-15	11,818,159	13.87	+5.9%

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