SCHEDULE 13G Filed 2026-10-01 Event — SEC 0001104659-26-112828 →

Paradigm Biocapital Advisors LP → Spyre Therapeutics, Inc. SYRE

Stake: — Shares: — Class: Common Stock, $0.0001 par value per share

Item 4 — Purpose of Transaction

Not extracted from this filing — typically because it's an amendment (13D/A) and Item 4 is unchanged from the parent filing. Read the raw SEC filing →

Cross-References

Insider Activity (last 365d)

75 transactions

0 buys · 61 sales · 12 awards/exercises

Issuer Cluster

6 13D/G filings on this issuer

5 other filings besides this one

Filer Track Record

4 filings by this filer

3 other filings in the data moat

Short Interest · settle 2026-09-30

DTC 8.89

12,844,608 shares short · +5.9% vs prior

Institutional Consensus · 2025-12-31

Held by elite portfolio managers

1 holder · $21.70M

Point72 Asset Mgmt

Form 4 Insider Transactions · last 365d

Date	Insider	Role	Type	Shares	Price	Value
2026-10-01	King-Jones Heidy	officer	Option exercise	28,933	$14.50	$420K
2026-10-01	King-Jones Heidy	officer	Sale	400	$89.24	$36K
2026-10-01	King-Jones Heidy	officer	Sale	16,605	$90.35	$1.50M
2026-10-01	King-Jones Heidy	officer	Sale	7,228	$91.35	$660K
2026-10-01	King-Jones Heidy	officer	Sale	2,100	$92.70	$195K
2026-10-01	King-Jones Heidy	officer	Sale	2,600	$93.46	$243K
2026-10-01	Turtle Cameron	director, officer	Sale	600	$89.14	$53K
2026-10-01	Turtle Cameron	director, officer	Sale	2,683	$90.10	$242K
2026-10-01	Turtle Cameron	director, officer	Sale	2,638	$91.49	$241K
2026-10-01	Turtle Cameron	director, officer	Sale	3,989	$92.31	$368K
2026-10-01	Turtle Cameron	director, officer	Sale	4,990	$93.37	$466K
2026-10-01	Turtle Cameron	director, officer	Sale	100	$93.91	$9K
2026-10-01	Burrows Scott L	officer	Option exercise	7,500	$14.50	$109K
2026-10-01	Burrows Scott L	officer	Sale	600	$89.07	$53K
2026-10-01	Burrows Scott L	officer	Sale	1,500	$90.27	$135K
2026-10-01	Burrows Scott L	officer	Sale	2,100	$91.92	$193K
2026-10-01	Burrows Scott L	officer	Sale	3,071	$92.95	$285K
2026-10-01	Burrows Scott L	officer	Sale	229	$93.57	$21K
2026-09-30	Burrows Scott L	officer	Option exercise	17,500	$14.50	$254K
2026-09-30	Burrows Scott L	officer	Sale	17,500	$89.89	$1.57M
2026-09-02	King-Jones Heidy	officer	Option exercise	400	$14.50	$6K
2026-09-02	King-Jones Heidy	officer	Sale	400	$90.00	$36K
2026-09-02	Burrows Scott L	officer	Sale	18,232	$89.35	$1.63M
2026-09-01	King-Jones Heidy	officer	Option exercise	27,999	$14.50	$406K
2026-09-01	King-Jones Heidy	officer	Sale	4,845	$86.40	$419K

Showing 25 of 75

Other 13D/G Filings on Spyre Therapeutics, Inc.

Filed	Form	Filer	Stake	Shares
2026-10-09	SCHEDULE 13D/A	Fairmount Funds Management LLC	9.99%	9,354,200	view →
2026-06-23	SCHEDULE 13D/A	Fairmount Funds Management LLC	—	8,835,440	view →
2023-12-11	SC	Fairmount Funds Management LLC	—	—	view →
2022-02-10	SC	BAKER BROS. ADVISORS LP	—	—	view →
2021-03-19	SC	BAKER BROS. ADVISORS LP	—	—	view →

Other Filings by Paradigm Biocapital Advisors LP

Filed	Form	Issuer	Stake	Shares
2026-09-17	SCHEDULE 13G	Tyra Biosciences, Inc.	—	—	view →
2026-06-26	SCHEDULE 13G	Viridian Therapeutics, Inc. VRDN	—	—	view →
2026-06-24	SCHEDULE 13G	MBX Biosciences, Inc. MBX	—	—	view →

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