SC Filed 2022-11-14 Event — SEC 0001387131-22-011406 →

GSK PLC → Spero Therapeutics, Inc. SPRO

Stake: — Shares: —

Composite Decision Signal · PASS (LOW BASE-RATE EDGE) Conviction Score: 10/100

Passive Schedule 13G filer baseline
Held by 1 tracked 13F institutional manager

Item 4 — Purpose of Transaction

Not extracted from this filing — typically because it's an amendment (13D/A) and Item 4 is unchanged from the parent filing. Read the raw SEC filing →

Cross-References

Insider Activity (last 365d)

8 transactions

8 buys · 0 sales · 0 awards/exercises

Issuer Cluster

6 13D/G filings on this issuer

5 other filings besides this one

Filer Track Record

23 filings by this filer

22 other filings in the data moat

Short Interest · settle 2026-10-15

DTC 1.51

840,529 shares short · +5.8% vs prior

Institutional Consensus · 2025-12-31

Held by elite portfolio managers

1 holder · $102K

Point72 Asset Mgmt

Form 4 Insider Transactions · last 365d

Date	Insider	Role	Type	Shares	Price	Value
2026-06-23	Deshpande Milind	director	Award	10,000	—	—
2026-06-23	Deshpande Milind	director	Award	20,000	$2.15	$43K
2026-06-23	Tregoning Kathleen	director	Award	10,000	—	—
2026-06-23	Tregoning Kathleen	director	Award	20,000	$2.15	$43K
2026-06-23	Smith Cynthia	director	Award	10,000	—	—
2026-06-23	Smith Cynthia	director	Award	20,000	$2.15	$43K
2026-06-23	VINK PATRICK V.J.J.	director	Award	10,000	—	—
2026-06-23	VINK PATRICK V.J.J.	director	Award	20,000	$2.15	$43K

Other 13D/G Filings on Spero Therapeutics, Inc.

Filed	Form	Filer	Stake	Shares
2021-09-16	SC	GLAXOSMITHKLINE PLC	—	—	view →
2021-02-16	SC	Atlas Venture Fund X, L.P.	—	—	view →
2020-12-07	SC	GLAXOSMITHKLINE PLC	—	—	view →
2020-06-04	SC	GLAXOSMITHKLINE PLC	—	—	view →
2018-07-17	SC	GLAXOSMITHKLINE PLC	—	—	view →

Other Filings by GSK PLC

Filed	Form	Issuer	Stake	Shares
2023-10-10	SC	Haleon plc HLNCF	—	—	view →
2022-09-20	SC	Theravance Biopharma, Inc. TBPH	—	—	view →
2022-02-10	SC	Theravance Biopharma, Inc. TBPH	—	—	view →
2021-09-16	SC	Spero Therapeutics, Inc. SPRO	—	—	view →
2021-09-16	SC	BICYCLE THERAPEUTICS plc BCYC	—	—	view →
2021-05-25	SC	Innoviva, Inc. INVA	—	—	view →
2021-04-16	SC	BICYCLE THERAPEUTICS plc BCYC	—	—	view →
2021-04-08	SC	Pandion Therapeutics, Inc.	—	—	view →
2021-02-12	SC	Innoviva, Inc. INVA	—	—	view →
2020-12-07	SC	Spero Therapeutics, Inc. SPRO	—	—	view →
2020-12-07	SC	BICYCLE THERAPEUTICS plc BCYC	—	—	view →
2020-10-01	SC	Principia Biopharma Inc.	—	—	view →
2020-06-29	SC	Morphic Holding, Inc.	—	—	view →
2020-06-22	SC	Theravance Biopharma, Inc. TBPH	—	—	view →
2020-06-04	SC	Spero Therapeutics, Inc. SPRO	—	—	view →
2020-02-27	SC	Theravance Biopharma, Inc. TBPH	—	—	view →
2019-04-18	SC	Theravance Biopharma, Inc. TBPH	—	—	view →
2018-07-17	SC	Spero Therapeutics, Inc. SPRO	—	—	view →
2018-04-10	SC	Innoviva, Inc. INVA	—	—	view →
2018-02-13	SC	HTG MOLECULAR DIAGNOSTICS, INC	—	—	view →

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