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ISSUER PROFILE · CIK 0001701108

Spero Therapeutics, Inc.SPRO

6 13D/G filings 2 distinct filers 0 insider transactions (365d)

Cross-Reference Snapshot

Activist filings
6
6 SC
Distinct filers
2
multi-activist cluster
Insiders (365d)
0
0 buys · 0 sales
Latest short DTC
1.96
as of 2026-05-29

Institutional Consensus · 2025-12-31

Held by elite portfolio managers
1 holder · $102K
Point72 Asset Mgmt

13D/G Filings Timeline · 6 total

FiledFormFilerStakeSharesIntent
2022-11-14 SC GSK PLC view →
2021-09-16 SC GLAXOSMITHKLINE PLC view →
2021-02-16 SC Atlas Venture Fund X, L.P. view →
2020-12-07 SC GLAXOSMITHKLINE PLC view →
2020-06-04 SC GLAXOSMITHKLINE PLC view →
2018-07-17 SC GLAXOSMITHKLINE PLC view →

FINRA Short Interest History

SettlementShort InterestDays to Cover% Δ vs prior
2026-05-29 1,706,545 1.96 +3.6%
2026-05-15 1,647,297 2.61 +39.6%
2026-04-30 1,179,702 3.06 +59.9%
2026-04-15 737,720 1.39 +21.9%
2026-03-31 605,311 1.86 +12.6%
2026-03-13 537,411 1.72 -6.4%
2026-02-27 574,027 2.12 -19.8%
2026-02-13 715,694 1.68 -24.0%
2026-01-30 941,659 4.01 -9.4%
2026-01-15 1,039,613 4.43 +9.8%
2025-12-31 946,767 3.85 -10.3%
2025-12-15 1,056,013 3.51 +27.9%

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