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ISSUER PROFILE · CIK 0001701108

Spero Therapeutics, Inc.SPRO

6 13D/G filings 2 distinct filers 8 insider transactions (365d)

Cross-Reference Snapshot

Activist filings
6
6 SC
Distinct filers
2
multi-activist cluster
Insiders (365d)
8
8 buys · 0 sales
Latest short DTC
1.51
as of 2026-10-15

Institutional Consensus · 2025-12-31

Held by elite portfolio managers
1 holder · $102K
Point72 Asset Mgmt

13D/G Filings Timeline · 6 total

FiledFormFilerStakeSharesIntent
2022-11-14 SC GSK PLC — — view →
2021-09-16 SC GLAXOSMITHKLINE PLC — — view →
2021-02-16 SC Atlas Venture Fund X, L.P. — — view →
2020-12-07 SC GLAXOSMITHKLINE PLC — — view →
2020-06-04 SC GLAXOSMITHKLINE PLC — — view →
2018-07-17 SC GLAXOSMITHKLINE PLC — — view →

Form 4 Insider Transactions · last 365d

DateInsiderRoleTypeSharesPriceValue
2026-06-23 Deshpande Milind director Award 10,000 — —
2026-06-23 Deshpande Milind director Award 20,000 $2.15 $43K
2026-06-23 Tregoning Kathleen director Award 10,000 — —
2026-06-23 Tregoning Kathleen director Award 20,000 $2.15 $43K
2026-06-23 Smith Cynthia director Award 10,000 — —
2026-06-23 Smith Cynthia director Award 20,000 $2.15 $43K
2026-06-23 VINK PATRICK V.J.J. director Award 10,000 — —
2026-06-23 VINK PATRICK V.J.J. director Award 20,000 $2.15 $43K

FINRA Short Interest History

SettlementShort InterestDays to Cover% Δ vs prior
2026-10-15 840,529 1.51 +5.8%
2026-09-30 794,509 1.00 -18.6%
2026-09-15 976,488 3.06 -19.3%
2026-08-31 1,210,417 2.95 -16.3%
2026-08-14 1,445,879 1.90 -4.5%
2026-07-31 1,513,354 1.00 -28.4%
2026-07-15 2,113,935 1.28 -26.2%
2026-06-30 2,864,850 1.04 +56.4%
2026-06-15 1,831,713 2.25 +7.3%
2026-05-29 1,706,545 1.96 +3.6%
2026-05-15 1,647,297 2.61 +39.6%
2026-04-30 1,179,702 3.06 +59.9%

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