PERCEPTIVE ADVISORS LLC → LeonaBio, Inc. LONA

Item 4 of the Schedule 13D is amended and supplemented as follows: On August 22, 2026, Sermonix notified the Reporting Persons that it will distribute Sermonix Pre-Funded Warrants exercisable for 2,352,932 shares of Common Stock to PXV II pursuant to a distribution of securities to owners of Sermonix's common stock. The distribution is expected to be effective on October 26, 2026. Pursuant to the terms of the Sermonix Pre-Funded Warrants, the pre-funded warrants that will be held by PXV II will not be exerciseable to the extent that such exercise would result in beneficial ownership in excess of 19.99% of the outstanding shares of Common Stock of the Issuer.