SCHEDULE Filed 2025-01-31 Event 2025-01-31 SEC 0000950170-25-011961 →

PERCEPTIVE ADVISORS LLC → Nautilus Biotechnology, Inc. NAUT

Stake: 10.00% Shares: 12,594,211 CUSIP: 63909J108 Class: Common Stock, par value $0.0001 per share

Item 4 — Purpose of Transaction

Item 4 of the Schedule 13D is hereby amended and supplemented as follows: On January 28, 2025, Michael Altman, a Managing Director of Perceptive Advisors who has served on the Issuer's board of directors (the "Board") since June 2021, informed the Issuer that he will not stand for reelection to the Board at the Issuer's 2025 Annual Meeting of Stockholders (the "Annual Meeting"). Mr. Altman will remain a member of the Board until the conclusion of the Annual Meeting.

Cross-References

Insider Activity (last 365d)

0 transactions

0 buys · 0 sales · 0 awards/exercises

Issuer Cluster

6 13D/G filings on this issuer

5 other filings besides this one

Filer Track Record

28 filings by this filer

27 other filings in the data moat

Short Interest · settle 2026-07-15

DTC 1.30

1,448,757 shares short · +74.7% vs prior

Institutional Consensus · 2025-12-31

Held by elite portfolio managers

1 holder · $119K

Point72 Asset Mgmt

Post-Filing Returns · since 2025-01-31 on NAUT

+1 day

0.0%

+5 days

0.0%

+30 days

0.0%

+60 days

0.0%

+90 days

0.0%

+180 days

0.0%

Anchor price 1.69 on closest trading day on/after 2025-01-31. Source: Yahoo Finance daily adj_close (split + dividend adjusted).

Other 13D/G Filings on Nautilus Biotechnology, Inc.

Filed	Form	Filer	Stake	Shares
2026-06-30	SCHEDULE 13D/A	AH Bio Fund II, L.P.	—	8,366,966	view →
2026-06-04	SCHEDULE 13D/A	AH Bio Fund II, L.P.	9.90%	11,682,032	view →
2025-03-05	SCHEDULE	Patel Sujal M	15.70%	20,297,732	view →
2025-03-05	SCHEDULE	Mallick Parag	17.40%	22,263,911	view →
2023-03-01	SC	Nautilus Biotechnology, Inc.	—	—	view →

Other Filings by PERCEPTIVE ADVISORS LLC

Filed	Form	Issuer	Stake	Shares
2026-07-23	SCHEDULE 13G	Freenome, Inc.	—	—	view →
2026-07-20	SCHEDULE 13G	Research Alliance Corporation IV	—	—	view →
2026-06-25	SCHEDULE 13D	Kardigan, Inc. KARD	8.90%	8,254,144	view →
2026-01-26	SCHEDULE	TRINITY BIOTECH PLC TRIB	9.90%	1,463,058,248	view →
2026-01-02	SCHEDULE	MeiraGTx Holdings plc MGTX	12.90%	10,441,562	view →
2025-02-21	SCHEDULE	Solid Biosciences Inc. SLDB	15.60%	11,934,679	view →
2025-02-14	SCHEDULE	TRINITY BIOTECH PLC TRIB	20.90%	85,800,000	view →
2023-10-17	SC	Cerevel Therapeutics Holdings, Inc.	—	—	view →
2023-06-06	SC	SOLENO THERAPEUTICS INC SLNO	—	—	view →
2023-05-30	SC	SOLENO THERAPEUTICS INC SLNO	—	—	view →
2023-05-25	SC	SOLENO THERAPEUTICS INC SLNO	—	—	view →
2023-04-25	SC	Cerevel Therapeutics Holdings, Inc.	—	—	view →
2022-12-06	SC	Solid Biosciences Inc. SLDB	—	—	view →
2022-07-01	SC	Athira Pharma, Inc. LONA	—	—	view →
2022-04-14	SC	Lyra Therapeutics, Inc. LYRA	—	—	view →
2022-03-02	SC	AMICUS THERAPEUTICS, INC. FOLD	—	—	view →
2021-06-25	SC	CATABASIS PHARMACEUTICALS INC	—	—	view →
2021-04-06	SC	Landos Biopharma, Inc.	—	—	view →
2021-03-23	SC	Solid Biosciences Inc. SLDB	—	—	view →
2020-12-17	SC	Solid Biosciences Inc. SLDB	—	—	view →

Showing 20 of 27

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