| Filed | Form | Filer | Stake | Shares | Intent | |
|---|---|---|---|---|---|---|
| 2026-10-13 | SCHEDULE 13G | JPMORGAN CHASE & CO | — | — | view → | |
| 2020-06-26 | SC | MPM BIOVENTURES V, L.P. | — | — | view → | |
| 2020-02-05 | SC | MPM BIOVENTURES V, L.P. | — | — | view → | |
| 2019-02-12 | SC | MPM BIOVENTURES V, L.P. | — | — | view → | |
| 2018-02-07 | SC | ORBIMED ADVISORS LLC | — | — | view → |
| Date | Insider | Role | Type | Shares | Price | Value |
|---|---|---|---|---|---|---|
| 2026-09-14 | Meeker David P | director, officer | Option exercise | 50,000 | $6.05 | $303K |
| 2026-09-14 | Meeker David P | director, officer | Sale | 6,439 | $101.75 | $655K |
| 2026-09-14 | Meeker David P | director, officer | Sale | 30,746 | $102.35 | $3.15M |
| 2026-09-14 | Meeker David P | director, officer | Sale | 8,698 | $103.43 | $900K |
| 2026-09-14 | Meeker David P | director, officer | Sale | 1,817 | $104.55 | $190K |
| 2026-09-14 | Meeker David P | director, officer | Sale | 2,300 | $105.19 | $242K |
| 2026-08-13 | Lee Jennifer Kayden | officer | Option exercise | 35,000 | $24.29 | $850K |
| 2026-08-13 | Lee Jennifer Kayden | officer | Option exercise | 21,601 | $6.80 | $147K |
| 2026-08-13 | Lee Jennifer Kayden | officer | Sale | 75,834 | $117.38 | $8.90M |
| 2026-08-12 | Mazabraud Yann | officer | Option exercise | 46,625 | $6.80 | $317K |
| 2026-08-12 | Mazabraud Yann | officer | Sale | 2,300 | $111.80 | $257K |
| 2026-08-12 | Mazabraud Yann | officer | Sale | 1,000 | $112.86 | $113K |
| 2026-08-12 | Mazabraud Yann | officer | Sale | 3,605 | $114.70 | $413K |
| 2026-08-12 | Mazabraud Yann | officer | Sale | 14,568 | $115.43 | $1.68M |
| 2026-08-12 | Mazabraud Yann | officer | Sale | 18,208 | $116.49 | $2.12M |
| 2026-08-12 | Mazabraud Yann | officer | Sale | 17,319 | $117.47 | $2.03M |
| 2026-04-01 | Mazabraud Yann | officer | Option exercise | 12,875 | — | — |
| 2026-04-01 | Popovits Kimberly J | director | Award | 6,808 | — | — |
| 2026-04-01 | Popovits Kimberly J | director | Award | 10,257 | $88.12 | $904K |
| 2026-04-01 | Mazabraud Yann | officer | Option exercise | 10,375 | — | — |
| 2026-04-01 | Mazabraud Yann | officer | Option exercise | 2,500 | — | — |
| 2026-03-12 | Mathers Edward T | director | J | 4,199 | — | — |
| 2026-03-04 | German Christopher Paul | officer | Option exercise | 1,500 | $17.97 | $27K |
| 2026-03-04 | German Christopher Paul | officer | Sale | 5,614 | $89.56 | $503K |
| 2026-03-02 | Mazabraud Yann | officer | Award | 35,000 | $94.94 | $3.32M |
| Settlement | Short Interest | Days to Cover | % Δ vs prior |
|---|---|---|---|
| 2026-09-30 | 10,767,698 | 14.14 | +4.7% |
| 2026-09-15 | 10,287,811 | 20.06 | -0.1% |
| 2026-08-31 | 10,303,031 | 21.89 | +1.5% |
| 2026-08-14 | 10,154,327 | 12.24 | +7.6% |
| 2026-07-31 | 9,440,417 | 16.17 | -1.4% |
| 2026-07-15 | 9,574,527 | 13.74 | -0.9% |
| 2026-06-30 | 9,665,089 | 7.57 | +20.7% |
| 2026-06-15 | 8,005,303 | 11.58 | +1.2% |
| 2026-05-29 | 7,911,004 | 14.78 | -4.5% |
| 2026-05-15 | 8,282,367 | 8.28 | +2.8% |
| 2026-04-30 | 8,057,652 | 14.55 | +2.9% |
| 2026-04-15 | 7,830,912 | 12.81 | +2.7% |
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