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SCHEDULE Filed 2025-02-18 Event 2025-02-18 SEC 0000950170-25-022688 →

ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI GeneDx Holdings Corp. WGSWW

Stake: 6.10% Shares: 1,680,016 CUSIP: 81663L101 Class: Class A Common Stock

Item 4 — Purpose of Transaction

Item 4 is hereby amended and supplemented as follows: On January 30, 2025, ISMMS sold 200,000 shares of Class A Common Stock at a price of $78.50 per share. On February 13, 2025, ISMMS sold 400,000 shares of Class A Common Stock at a price of $77.5776 per share, on February 14, 2025, ISMMS sold 89,676 shares of Class A Common Stock at a price of $76.9296 per share, and on February 18, 2025, ISMMS sold 350,000 shares of Class A Common Stock at a price of $100.4069 per share. Each sale was made in reliance on Rule 144 promulgated under the Securities Act of 1933. ISMMS previously filed a Form 144 on January 30, 2025, disclosing ISMMS's intention to sell up to 1,346,123 shares of Class A Common Stock within the next 90 days, which amount includes the aggregate 1,039,676 shares sold as described above. The information in Item 3 of the Schedule 13D is incorporated by reference into this Item 4. The Reporting Persons expect to evaluate on an ongoing basis the Issuer's financial condition and prospects and their respective interests in, and intentions with respect to, the Issuer and their respective investments in the securities of the Issuer, which review may be based on various factors, including the Issuer's business and financial condition, results of operations and prospects, general economic and industry conditions, the securities markets in general and those for the Issuer's securities in particular, as well as other developments and other investment opportunities. Accordingly, each Reporting Person reserves the right to change its intentions, as it deems appropriate. In particular, each Reporting Person may, at any time and from time to time, in the open market, in privately negotiated transactions or otherwise, increase its holdings in the Issuer or dispose of all or a portion of the securities of the Issuer that such Reporting Person now owns or may hereafter acquire, including sales pursuant to the exercise of the registration rights provided for in the Subscription Agreements or in the Registration Rights Agreement described in the Schedule 13D. Except as described in the Schedule 13D, the Reporting Persons do not have any present plans or proposals that relate to or would result in any of the actions described in subparagraphs (a) through (j) of Item 4 of Schedule 13D, although, subject to the agreements described herein, the Reporting Persons, at any time and from time to time, may review, reconsider and change their position and/or change their purpose and/or develop such plans and may seek to influence management or the board of the Issuer with respect to the business and affairs of the Issuer and may from time to time consider pursuing or proposing such matters with advisors, the Issuer or other persons.

Cross-References

Insider Activity (last 365d)
3 transactions
3 buys · 0 sales · 0 awards/exercises
Issuer Cluster
10 13D/G filings on this issuer
9 other filings besides this one
Filer Track Record
3 filings by this filer
2 other filings in the data moat
Short Interest · settle 2026-07-15
DTC 1.00
18,319 shares short · -64.1% vs prior

Institutional Consensus · 2025-12-31

Held by elite portfolio managers
1 holder · $1.24M
Point72 Asset Mgmt

Post-Filing Returns · since 2025-02-18 on WGSWW

+1 day
0.0%
+5 days
0.0%
+30 days
0.0%
+60 days
0.0%
+90 days
0.0%
+180 days
0.0%

Anchor price 0.00 on closest trading day on/after 2025-02-18. Source: Yahoo Finance daily adj_close (split + dividend adjusted).

Form 4 Insider Transactions · last 365d

DateInsiderRoleTypeSharesPriceValue
2026-05-20 Casdin Capital, LLC director, 10%+ owner Buy 140,000 $43.81 $6.13M
2026-05-19 Casdin Capital, LLC director, 10%+ owner Buy 185,000 $42.60 $7.88M
2026-05-18 Casdin Capital, LLC director, 10%+ owner Buy 175,000 $42.55 $7.45M

Other 13D/G Filings on GeneDx Holdings Corp.

FiledFormFilerStakeShares
2026-05-22 SCHEDULE 13D/A CMLS Holdings LLC 17.90% 537,285 view →
2026-05-15 SCHEDULE 13D/A CMLS Holdings LLC 17.90% 537,285 view →
2026-05-11 SCHEDULE 13D/A CMLS Holdings LLC 537,285 view →
2025-02-21 SCHEDULE ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI 4.89% 1,373,569 view →
2024-07-05 SC OPKO HEALTH, INC. view →
2022-12-05 SC CMLS Holdings LLC view →
2022-01-21 SC ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI view →
2022-01-20 SC Blackstone Holdings III L.P. view →
2022-01-19 SC CMLS Holdings LLC view →

Other Filings by ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

FiledFormIssuerStakeShares
2025-02-21 SCHEDULE GeneDx Holdings Corp. WGSWW 4.89% 1,373,569 view →
2022-01-21 SC Sema4 Holdings Corp. WGSWW view →

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