SCHEDULE Filed 2025-09-17 Event 2025-09-12 SEC 0001829126-25-007447 →

Avenue Venture Opportunities Fund, L.P. → HYPERION DEFI, INC. HYPD

Stake: 6.20% Shares: 354,291 CUSIP: 30234E203 Class: COMMON STOCK, par value $0.0001 per share

Composite Decision Signal · PASS (LOW BASE-RATE EDGE) Conviction Score: 16/100 · Filer 90d Win Rate: 0% · Hist. 90d Edge: +0.0%

Passive Schedule 13G filer baseline
Moderate short days-to-cover (3.7 DTC)
Short interest building (+14.6% vs prior settlement)

Item 4 — Purpose of Transaction

(a) - (c) The information set forth in Item 4 of the Scheule 13D is incorporated by reference. This Amendment is being filed to report a change in Reporting Persons' beneficial ownership due to an increase in Issuer's outstanding shares of Common Stock.

Cross-References

Insider Activity (last 365d)

0 transactions

0 buys · 0 sales · 0 awards/exercises

Issuer Cluster

15 13D/G filings on this issuer

14 other filings besides this one

Filer Track Record

2 filings by this filer

1 other filing in the data moat

Short Interest · settle 2026-10-15

DTC 3.72

1,296,352 shares short · +14.6% vs prior

Post-Filing Returns · since 2025-09-12 on HYPD

+1 day

0.0%

+5 days

0.0%

+30 days

0.0%

+60 days

0.0%

+90 days

0.0%

+180 days

0.0%

Anchor price 2.86 on closest trading day on/after 2025-09-12. Source: Yahoo Finance daily adj_close (split + dividend adjusted).

Other 13D/G Filings on HYPERION DEFI, INC.

Filed	Form	Filer	Stake	Shares
2026-07-01	SCHEDULE 13G/A	Forsakringsaktiebolaget Avanza Pension	—	—	view →
2025-06-20	SCHEDULE	Avenue Venture Opportunities Fund, L.P.	9.99%	435,438	view →
2023-01-24	SC	Ianchulev Tsontcho	—	—	view →
2022-02-08	SC	Grant Stuart M.	—	—	view →
2021-12-27	SC	Grant Stuart M.	—	—	view →
2021-06-10	SC	Grant Stuart M.	—	—	view →
2020-11-25	SC	Ianchulev Tsontcho	—	—	view →
2020-11-13	SC	Grant Stuart M.	—	—	view →
2020-08-24	SC	Grant Stuart M.	—	—	view →
2020-08-14	SC	ESHELMAN FREDRIC N	—	—	view →
2020-08-14	SC	Ianchulev Tsontcho	—	—	view →
2019-08-20	SC	ESHELMAN FREDRIC N	—	—	view →
2019-07-18	SC	Ianchulev Tsontcho	—	—	view →
2019-01-11	SC	Ianchulev Tsontcho	—	—	view →

Other Filings by Avenue Venture Opportunities Fund, L.P.

Filed	Form	Issuer	Stake	Shares
2025-06-20	SCHEDULE	EYENOVIA, INC. HYPD	9.99%	435,438	view →

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