SCHEDULE 13D/A Filed 2026-09-17 Event 2026-09-15 SEC 0001346824-26-000237 →

RA CAPITAL MANAGEMENT, L.P. → TYRA BIOSCIENCES, INC. TYRA

Stake: — Shares: 14,130,492 Class: Common Stock, $0.0001 par value per share

Composite Decision Signal · PASS (LOW BASE-RATE EDGE) Conviction Score: 29/100 · Filer 90d Win Rate: 0% · Hist. 90d Edge: +0.0%

Filer track record (20 filings): 0% 90d win rate, +0.0% 90d edge
Held by 1 tracked 13F institutional manager
Elevated short days-to-cover (15.3 DTC)

Item 4 — Purpose of Transaction

Not extracted from this filing — typically because it's an amendment (13D/A) and Item 4 is unchanged from the parent filing. Read the raw SEC filing →

Cross-References

Insider Activity (last 365d)

0 transactions

0 buys · 0 sales · 0 awards/exercises

Issuer Cluster

4 13D/G filings on this issuer

3 other filings besides this one

Filer Track Record

88 filings by this filer

87 other filings in the data moat

Short Interest · settle 2026-10-15

DTC 15.33

9,495,754 shares short · +0.9% vs prior

Institutional Consensus · 2025-12-31

Held by elite portfolio managers

1 holder · $22.98M

Point72 Asset Mgmt

Other 13D/G Filings on TYRA BIOSCIENCES, INC.

Filed	Form	Filer	Stake	Shares
2026-09-21	SCHEDULE 13G	BIOTECHNOLOGY VALUE FUND L P	—	—	view →
2026-09-17	SCHEDULE 13G	Paradigm Biocapital Advisors LP	—	—	view →
2024-10-15	SC	Boxer Capital, LLC	—	—	view →

Other Filings by RA CAPITAL MANAGEMENT, L.P.

Filed	Form	Issuer	Stake	Shares
2026-10-26	SCHEDULE 13G	Alector, Inc.	—	—	view →
2026-10-22	SCHEDULE 13G	Frazier Life Sciences Acquisition Corp. II	—	—	view →
2026-09-22	SCHEDULE 13G	BetterLife Pharma Inc.	—	—	view →
2026-09-21	SCHEDULE 13D/A	SIONNA THERAPEUTICS, INC.	14.30%	6,476,193	view →
2026-09-03	SCHEDULE 13G	JATT III Acquisition Corp	—	—	view →
2026-08-17	SCHEDULE 13G	Latigo Biotherapeutics, Inc.	—	—	view →
2026-08-14	SCHEDULE 13D/A	SEPTERNA, INC.	—	5,525,324	view →
2026-08-11	SCHEDULE 13D/A	Wave Life Sciences, Inc.	—	34,314,406	view →
2026-08-10	SCHEDULE 13D/A	SAB Biotherapeutics, Inc.	—	9,609,852	view →
2026-07-23	SCHEDULE 13D/A	ARTIVA BIOTHERAPEUTICS, INC.	—	18,415,956	view →
2026-07-22	SCHEDULE 13D/A	Freenome, Inc.	—	15,367,270	view →
2026-07-21	SCHEDULE 13D/A	VOR BIOPHARMA INC.	—	12,937,855	view →
2026-07-20	SCHEDULE 13G	Agenus Inc.	—	—	view →
2026-07-07	SCHEDULE 13D/A	Climb Bio, Inc. CLYM	33.00%	23,249,186	view →
2026-07-02	SCHEDULE 13D/A	WEREWOLF THERAPEUTICS, INC. HOWL	4.10%	1,985,541	view →
2026-06-26	SCHEDULE 13D/A	WEREWOLF THERAPEUTICS, INC. HOWL	6.00%	2,915,742	view →
2026-06-24	SCHEDULE 13D/A	SOLID BIOSCIENCES INC. SLDB	—	12,036,126	view →
2026-06-22	SCHEDULE 13D/A	WEREWOLF THERAPEUTICS, INC. HOWL	—	3,654,307	view →
2026-06-18	SCHEDULE 13D	Parabilis Medicines, Inc. PBLS	23.80%	28,933,371	view →
2026-06-15	SCHEDULE 13D/A	WEREWOLF THERAPEUTICS, INC. HOWL	—	5,138,703	view →

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